在患有血液性恶性瘤的患者中评估和保持生育能力
Xiang Wang1, Ruihao Huang2, Lei Liu1
1Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Institute of Science Innovation for Blood Ecology and Intelligent Cells, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China; State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University, Chongqing, 400037, China; Jinfeng Laboratory, Chongqing, 400037, China.
Cancer letters
|February 21, 2025
概括
新型癌症疗法改善了血液恶性瘤的生存率,但可能会损害生育能力. 血液学家必须与患者讨论生育保存的选择,特别是对于像青春期前的个体这样具有挑战性的病例.
科学领域:
- 在瘤学瘤学.
- 生殖医学 生殖医学
- 血液学 血液学 血液学
背景情况:
- 血液性恶性瘤的新疗法提高了存活率.
- 生育率下降是影响患者生活质量的重大问题.
- 众所周知,化学疗法和放射疗法等常规治疗方法会导致不孕.
研究的目的:
- 审查新型癌症治疗对生育能力的影响.
- 突出癌症患者生育能力保护方面的挑战.
- 强调患者教育的必要性和标准化的生育保护策略.
主要方法:
- 关于癌症治疗及其对生育能力的影响的最新文献的综述.
- 对男性和女性患者现有的生育保存技术的分析.
- 讨论与青春期前个体的生育能力保护相关的挑战.
主要成果:
- 针对针对性疗法和CAR-T细胞疗法等较新的治疗方法对生育效应的数据有限.
- 标准的生育保存方法包括冷保存精子,胚胎,卵细胞和卵巢组织.
- 在青春期前的患者中,保持生育能力仍然是一个重大的临床挑战.
结论:
- 血液学家必须向患者咨询癌症治疗可能引起的淋巴腺毒性.
- 提供适当的生育保护选择对于维持患者长期生活质量至关重要.
- 需要进一步的研究来解决生育保护的挑战,特别是在新疗法和青春期前患者.
相关概念视频
Infertility in Males
230
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
230
Regulation of Hematopoietic Stem Cells
3.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.1K
Bone Marrow Sampling and Transplants
274
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
274


