隔离和物理修饰对释放特性的影响 欧亚莱费洛克斯 Salisb 多糖化合物
1Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Jharkhand 835215, India.
International journal of biological macromolecules
|February 21, 2025
概括
改性makhana粉显示出对结肠向药物输送的承诺. 这些植物性辅助剂为治疗炎症性肠道疾病提供了增强的延缓释放性质.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 传统的辅助剂在药物输送方面存在局限性.
- 欧里亚尔费洛克斯·萨利斯伯特 (Euryale ferox Salisb.) 的一个地方. (makhana) 粉是一种未充分利用的植物性资源.
- 针对结肠的药物输送需要具有特定释放特性的辅助剂.
研究的目的:
- 调查原生和改性makhana粉作为辅助剂用于结肠向药物输送.
- 通过物理修改来增强马卡纳粉的延迟释放特性.
- 评估改性makhana粉适用于治疗炎症性肠道疾病的适用性.
主要方法:
- 马卡纳粉的物理修饰:先凝化,逆向化,超声波化,自闭槽加热,透压处理.
- 使用FTIR和XRD进行表征,以分析结构和分子变化.
- 在模拟胃 (pH1.2) 和肠道 (pH6.8) 介质中的体外溶解研究.
- 使用Korsmeyer-Peppas模型分析药物释放动力学.
主要成果:
- 改性粉表现出改善的膨胀,溶解性和保持水分的能力.
- FTIR和XRD证实了改性粉的结构重组和增强的结晶性.
- 基于粉的片剂显示出胃保护性质 (在pH 1.2下药物释放率<25%).
- 逆向粉 (RMS) 和先化粉 (PS-60) 在pH值为6.8时显示持续释放,在6h时药物释放率为55-60%.
- 科尔斯迈耶-佩帕斯模型最好地描述了RMS和PS-60的释放动力学,表明了扩散和侵蚀机制.
结论:
- 改性makhana粉是一种可行的,可持续的替代传统辅助剂.
- 增强的功能和延迟释放特性使其适合于结肠特异性药物输送.
- 这种方法有可能改善炎症性肠道疾病的治疗.
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