增强的双药加载 κ-carrageenan/agar 水凝膜用于伤口包裹:优化胀和药物释放
Shirin Arayesh1, Bahareh Tanhaei1, Saeedeh Movaghar Khoshkho1
1Department of Chemical Engineering, Faculty of Advanced Technologies, Quchan University of Technology, Quchan, Iran.
International journal of biological macromolecules
|February 21, 2025
概括
使用天然生物聚合物 κ-卡拉基南和阿加的新型抗菌水凝膜对伤口愈合有希望. 这些膜增强药物释放,并对常见的伤口细菌表现出强烈的抗菌活性.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 伤口治愈研究研究 伤口治愈研究
背景情况:
- 天然生物聚合物,如 κ-carrageenan 和 agar,为伤口带提供生物相容性.
- 开发有效的伤口护理解决方案需要具有抗微生物特性和可控制药物释放的材料.
研究的目的:
- 开发和描述 κ-carrageenan 和 agar 的抗菌水凝膜,用于伤口愈合.
- 为了评估四环素,针头提取物和Triton X-100对水凝特性和药物释放的影响.
- 评估开发的水凝膜的胀,药物释放,抗菌活性和机械性能.
主要方法:
- 凝膜是使用 κ-carrageenan 和 agar 合成的,与 KCl.交联.
- 为了抗微生物作用,添加了四环素 (TC) 和子提取物;用于增强药物的溶解性,使用了Triton X-100 (TX-100).
- 评估了胀行为,药物释放动力学,对大肠杆菌和金黄色杆菌的抗菌疗效,机械强度和水蒸气透性.
主要成果:
- 在蒸水中,水凝的最大膨胀率为399%,在模拟伤口液 (SWF) 中为222%,在酸盐缓冲盐溶液 (PBS) 中为124%.
- 药物释放受到介质和爪度的显著影响,SWF的释放最高.
- 水凝膜显示出大肠杆菌和金黄色细菌的大量抑制,机械强度高达438.364g.
结论:
- 开发的k-carrageenan-agar水凝薄膜装有TC和针叶提取物,显示出作为先进的伤口护理材料的巨大潜力.
- 增强的药物溶解性和释放性,加上强大的抗菌活性和良好的机械性能,支持它们在感染控制和伤口愈合中的应用.
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