介质的奥利沃耳间隔通路在响应听力损失时增强耳放大
Patricia M Quiñones1, Michelle Pei1, Hemant Srivastava2,3
1Caruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, California 90033.
概括
中间橄耳 (MOC) 效应慢性上调耳放大与听力损失,但不急性与大脑状态变化. 这一途径可能有助于补偿听力损失和相关症状.
科学领域:
- 神经科学是一个神经科学.
- 听觉生理学 听觉生理学
- 感官系统 感官系统
背景情况:
- 哺乳动物的耳从大脑收到不同的反,在注意力和保护对声学创伤方面发挥了假设的作用.
- 以前的研究受到了无法直接测量清醒动物的情感效应的限制.
研究的目的:
- 为了研究中介性橄耳 (MOC) 消极神经纤维在耳放大中的作用.
- 区分MOC对听觉处理的影响的短期和长期影响.
主要方法:
- 在清醒和麻醉小鼠中测量了科尔蒂器官对声音的振动反应.
- 利用了对无源和/或有源神经纤维的基因切除 (VGLUT3-/-和VGLUT3-/- Alpha9-/-小鼠).
- 使用瞳孔测量来评估神经调节性大脑状态及其对听觉反应的影响.
主要成果:
- 耳放大随着脱差而增加,当传感器完好无损时,这与外部毛细胞 (OHC) 和支持细胞的活性增加有关.
- 删除两个 afferents 和 efferents 否定了这种放大增加.
- 没有观察到耳放大或听觉脑干反应的急性状态依赖,尽管下游大脑区域显示状态依赖.
结论:
- 作为对听力损失的反应,MOC 效应慢性上调耳放大.
- 这种异常通路并不能根据大脑状态波动来敏调节耳放大.
- MOC 效应系统可能会部分补偿听力损失和相关症状,如耳和声音过大.
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