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Updated: May 26, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

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介质状态的结构异质性促进了CRIPT对PDZ3的结合领域:从分子动力学和马尔科夫状态模型分析的洞察力

Xingyu Song1, Dongdong Wang2, Jie Ji1

  • 1Department of Chemistry, Institute of Biomedical Sciences and Multiscale Research Institute of Complex Systems, Fudan University, Shanghai 200438, China.

Journal of chemical theory and computation
|February 21, 2025
PubMed
概括

内在无序的蛋白质 (IDP) 通过探索多种构造来快速结合目标. 这项研究揭示了类似漏斗的景观和加速结合的动态相互作用,为IDP功能提供了新的见解.

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