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根据NHANES调查,当前的相对脂肪量与女性不孕症史之间的关联

Dong Liu^1,2, Xiaoyan Luo^1,2, Kunyan Zhou^3,4

¹Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.

Scientific reports

|February 21, 2025

概括

较高的相对脂肪量 (RFM) 与女性不育率的增加有关. 这种较新的身体脂肪评估工具显示了比传统方法更强烈的关联,特别是在年轻女性中.

科学领域:

生殖健康生殖健康
内分泌学在内分泌学.
公共卫生公共卫生

背景情况:

不孕症影响全球数百万人,身体脂肪增加是显著的危险因素.
传统的身体脂肪指标,如BMI和腰围,在准确评估身体成分方面存在局限性.
相对脂肪质量指数 (RFM) 提供了更精确的体脂肪测量方法,但其与不孕症的联系尚未得到充分证实.

研究的目的:

调查相对脂肪量 (RFM) 和女性不孕史之间的关联.
在不孕症的背景下,将RFM的实用性与传统的身体脂肪测量方法进行比较.

主要方法:

来自国家健康和营养检查调查 (NHANES) 的3915名18-45岁妇女的数据分析.
自我报告的不孕不育状态和RFM,使用经过验证的公式计算.
使用后勤回归模型来评估RFM与不孕不育之间的关系,并对共变量进行调整.

主要成果:

与非不孕妇女相比,有不孕史的女性表现出明显更高的RFM.
最高的RFM四分位数与几乎三倍更高的不孕史几率有关 (OR:2.87;95% CI:1.85-4.44).
这种关联在35岁以下的女性中更为明显,通过敏感性分析证实了强有力的发现.

结论:

较高的相对脂肪量与不孕症史有很强的关联.
由于其反映身体脂肪分布的准确性,RFM成为评估不孕症风险的潜在有价值工具.
需要进一步的研究来探索针对RFM用于不孕症管理的干预措施.

关键词:

体重指数 (Body Mass Index) 是一个指数.不孕症不孕不育不孕不育不孕不育国家健康和营养检查调查调查肥胖问题肥胖问题相对脂肪质量相对脂肪质量腰围腰围腰围腰围

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