通过IL6-STAT3信号传递,IL35调节与HBV相关的HCC进展
Mingran Zhou1,2, Yunhong Xia1,2, Shuomin Wang3,4
1Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230002, China.
Scientific reports
|February 21, 2025
概括
介素-35 (IL35) 在乙型肝炎病毒 (HBV) 感染中促进肝细胞癌 (HCC) 的进展. 抑制IL35和IL-6-STAT3通路可能提供新的HCC治疗策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 肝细胞癌 (HCC) 是一个主要的全球健康问题,乙型肝炎病毒 (HBV) 感染是主要原因.
- 调节免疫反应的细胞因子 - - 35 (IL35) 在与HBV相关的HCC中没有明确的作用.
- 了解IL35的功能对于开发向疗法至关重要.
研究的目的:
- 调查IL35在与HBV相关的HCC中的调节作用.
- 阐明IL35影响HCC发育的分子机制.
主要方法:
- 分析人类HBV相关HCC组织中的IL35表达.
- 检查HBV诱导 (特别是HBx) 对肝瘤细胞系IL35表达的影响.
- 调查IL35沉默对HCC细胞增殖,细胞亡,迁移和入侵的影响.
- 评估IL35沉默对IL-6-STAT3信号通路的影响.
主要成果:
- 在与HBV相关的HCC组织中,IL35表达升高.
- 诱导HBV,特别是HBx,增加了肝瘤细胞中的IL35表达.
- 沉默IL35抑制了细胞增殖,细胞循环进展,迁移和入侵,同时促进HBx诱导的HCC细胞的亡.
- 抑制IL35抑制IL-6表达和STAT3激活 (酸化和核导入),从而抑制IL-6-STAT3通路.
结论:
- 通过激活IL-6-STAT3信号通路,IL35促进了与HBV相关的HCC的进展.
- 沉默IL35通过抑制这种途径,有效地减轻HCC的进展.
- IL35代表了与HBV相关的HCC的潜在治疗标.
更多相关视频
11:34A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
2.1K
10:37Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
2.8K
相关概念视频
01:01Regulation of Hematopoietic Stem Cells
3.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.1K
01:24T Cell Types and Functions
830
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
830