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根据与CAF相关的分子特征预测结肠癌的免疫治疗预后和向治疗灵敏度
Leqian Ying1,2, Lu Zhang1,2, Yanping Chen1
1Department of Oncology, Zhongda Hospital, Medical School of Southeast University, 87 Dingjiaqiao, Nanjing, 210000, China.
Scientific reports
|February 21, 2025
概括
与癌症相关的纤维细胞 (CAFs) 影响结肠癌的进展. 一个新的CAFscore预测了不良预后和治疗耐药性,帮助结肠癌患者个性化治疗策略.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 免疫学 免疫学 免疫学
背景情况:
- 与癌症相关的纤维细胞 (CAFs) 显著调节瘤微环境 (TME).
- CAF对结肠癌预后和治疗结果的确切影响需要进一步阐明.
- 了解CAF的作用对于开发向性结肠癌治疗非常重要.
研究的目的:
- 在结肠癌中识别与CAF透相关的基因.
- 开发一个CAF分子特征 (CAFscore) 用于预后预测.
- 调查CAFscore与结肠癌临床病理特征,突变和治疗反应之间的关系.
主要方法:
- 在TCGA和GSE39582结肠癌队列上进行权重基因共同表达网络分析 (WGCNA).
- 单变Cox和LASSO回归分析用于构建CAF得分.
- 在高和低CAFscore组中分析临床病理特征,体质突变,免疫逃避和治疗反应.
主要成果:
- 确定了244个与CAF透相关的基因,其中11个影响整体存活率.
- 使用FSTL3,CRIP2和SLC2A3开发了CAF得分,与预后较差和恶性瘤增加密切相关.
- 较高的CAF得分与治疗耐药性,减少CD8+T细胞透,以及通过NAMPT相互作用的潜在免疫逃避机制有关.
结论:
- 该CAFscore作为结肠癌的重要预后生物标志物.
- CAF活动,特别是FSTL3表达,与免疫抑制和治疗耐药性相关.
- 该CAFscore可以指导个性化结肠癌治疗,并识别需要积极管理的患者.
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