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Updated: May 26, 2025

Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays
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与GDP相关的Rab37通过减弱STAT1转位来调节M2类瘤相关的巨细胞极化,从而降低了I型IFN通路的下调

Chen-Tai Hong1, You-En Yang2, Hsueh-Fen Juan3

  • 1Department of Pharmacology, College of Medicine, National Cheng Kung University, No.1, University Road, Tainan, 701, Taiwan.

British journal of cancer
|February 21, 2025
PubMed
概括

独立于囊泡运输的Rab37蛋白质通过隔离STAT1.1促进瘤相关巨细胞 (TAMs) 中的M2极化. 这种相互作用与晚期肺癌和患者生存率低下有关.

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