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分子探针用于免疫细胞的体内光学成像

Jing Liu¹, Penghui Cheng¹, Cheng Xu¹

¹School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore.

Nature biomedical engineering

|February 21, 2025

概括

分子探针使免疫细胞的非侵入性光学成像成为可能. 这项技术有助于了解免疫反应,诊断癌症和动脉样硬化等疾病,并预测治疗成功.

科学领域:

免疫学免疫学免疫学
生物医学光学生物医学光学
分子成像学分子成像学

背景情况:

了解免疫细胞的作用需要先进的检测方法.
光学成像探针提供免疫反应的非侵入性可视化.
最近的进展有助于实时监测免疫细胞功能.

研究的目的:

审查选择性免疫细胞成像分子探针的最新进展.
讨论探头设计原则和跨光学模式的性能.
突出疾病背景中的应用和转化机会.

主要方法:

开发用于特定免疫细胞向的分子探针.
利用各种光学成像模式进行可视化.
在不同疾病模型中对探头性能进行比较分析.

主要成果:

分子探针允许选择性成像免疫细胞,包括瘤透淋巴细胞.
在癌症免疫疗法,动脉样硬化和炎症条件中证明了应用.
探针在药物查和预测治疗结果方面显示出潜力.

结论:

光学分子探针对于促进免疫系统的理解至关重要.
这些探针为疾病诊断和预后提供了重要的潜力.
临床应用存在翻译方面的挑战和机遇.

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