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相关概念视频

The Ras Gene02:38

The Ras Gene

6.1K
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
6.1K
Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

9.7K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
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Long-term Depression01:03

Long-term Depression

2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
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Chemical Synapses01:26

Chemical Synapses

8.6K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
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相关实验视频

Updated: May 26, 2025

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
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Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

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不同的Ras单体形式在相反的方向调节突触可塑性.

Esperanza López-Merino1, Alba Fernández-Rodrigo1,2, Jessie G Jiang1

  • 1Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.

The EMBO journal
|February 21, 2025
PubMed
概括
此摘要是机器生成的。

小的GTPase Ras信号通路对记忆至关重要. 研究人员发现,H-Ras调解长期抑郁症,而K-Ras支持长期潜能,影响认知功能.

关键词:
在海马体内,海马体记忆 记忆 记忆 记忆 记忆拉索病变 (RASopathies) 是一种拉索病变.脊柱 脊柱 脊柱 脊柱 脊柱 脊柱mGluRR 在线观看

更多相关视频

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
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Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

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Presynaptically Silent Synapses Studied with Light Microscopy
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Presynaptically Silent Synapses Studied with Light Microscopy

Published on: January 4, 2010

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相关实验视频

Last Updated: May 26, 2025

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
09:07

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

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Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
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Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

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Presynaptically Silent Synapses Studied with Light Microscopy
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Presynaptically Silent Synapses Studied with Light Microscopy

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科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 遗传学 遗传学 是一个

背景情况:

  • 拉斯GTPase是一个关键的细胞内信号中心,对海马长期增强 (LTP) 和记忆形成至关重要.
  • 由于Ras信号的遗传变化导致的RAS病变与人类的认知障碍有关.
  • 不同的Ras异型在神经元功能和突触可塑性中的特定作用仍然在很大程度上未被定义.

研究的目的:

  • 阐明H-Ras和K-Ras异型在突触可塑性和记忆中的不同功能.
  • 研究H-Ras调节突触功能和认知过程的分子机制.

主要方法:

  • 利用转基因小鼠在体内研究H-Ras和K-Ras功能.
  • 研究了突触可塑性,包括长期强化 (LTP) 和甲基氨酸受体介导的长期抑郁症 (mGluR-LTD).
  • 分析了分子信号通路,包括c-Src,Erk激活和de novo蛋白质合成,以响应H-Ras激活.

主要成果:

  • 发现H-Ras,最丰富的大脑异型,可以调解mGluR-LTD,而不是LTP.
  • 在mGluR-LTD期间脊柱中的H-Ras激活需要c-Src并触发Erk激活和蛋白质合成.
  • 删除H-Ras损害了对象识别,社交和空间记忆.
  • 确定K-Ras是特别需要LTP的异型.
  • 观察到H-Ras和K-Ras的不同突触局部化.

结论:

  • H-Ras和K-Ras在调节突触可塑性方面表现出功能专业化,其中H-Ras介导LTD,K-Ras介导LTP.
  • 这些发现突出了Ras异型在神经元功能中的独特作用,并对理解与RAS病变相关的认知障碍产生影响.