免疫营养指标预测紧急胃肠道手术后老年患者的短期死亡率:一项回顾性研究
Zechuan Jin1, Tinghan Yang1, Ziqiang Wang2
1Colorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University, Guo Xue Xiang No. 37, Chengdu, 610041, China.
像mGPS,PNI和CONUT这样的免疫营养指标可以预测紧急胃肠道手术后老年人的短期死亡率. 这些因素为改善患者结果和外科风险评估提供了宝贵的见解.
科学领域:
- 老年人手术是一门老年手术.
- 手术瘤学手术瘤学
- 营养免疫学 营养免疫学
背景情况:
- 接受紧急胃肠道手术的老年患者面临高短期死亡风险.
- 确定可靠的手术前预测因子对于优化患者管理和结果至关重要.
研究的目的:
- 确定能够预测经过紧急胃肠道手术的老年患者90天死亡率的免疫营养指标.
- 评估各种免疫营养标志物的预测性表现.
主要方法:
- 对4120名65岁以上的患者进行了回顾性分析,这些患者接受了紧急胃肠道手术.
- 用ROC和决策曲线分析评估免疫营养指标,包括mGPS,PNI和CONUT得分.
- 使用LASSO Cox和CoxBoost模型进行风险分层,并构建一个名ogram.
主要成果:
- 修改后的格拉斯哥预测评分 (mGPS),预测营养指数 (PNI) 和控制营养状况 (CONUT) 评分显示了对90天生存的良好预测准确性.
- 与LASSO Cox模型相比,CoxBoost模型在风险预测方面显示出更高的性能 (AUC).
- 使用LASSO考克斯选变量开发的名图表实现C指数为0.706.
结论:
- 免疫营养因素作为有利的手术前预测短期死亡率在接受紧急胃肠道手术的老年患者.
- 开发的诺米图为这种患者群体的风险分层和临床决策提供了有价值的工具.
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