恶性固体肺结节的危险因素:一个元分析
Yantao Yang1, Xuancheng Li2, Yaowu Duan1
1Department of Thoracic and Cardiovascular Surgery, Peking University Cancer Hospital Yunnan, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, No. 519 Kunzhou Road, Xishan District, Kunming City, Yunnan Province, China.
BMC cancer
|February 21, 2025
概括
恶性固体肺结节 (MSPN) 与良性固体肺结节 (BSPN) 相比,更有可能呈现状迹象,血管融合和球状特征. 这些成像特征,以及年龄,性别和家族史,有助于区分恶性和良性结节.
科学领域:
- 肺部病理学 肺部病理学
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 临床和成像特征可以帮助区分良性和恶性固体肺结节.
- 具体的区分特征仍然是争论的主题.
- 确定可靠的风险因素对于明智的临床决策至关重要.
研究的目的:
- 为了确定恶性固体肺结节 (MSPN) 的危险因素.
- 支持诊断肺结节的临床决策.
- 提供对与恶性瘤相关的成像和临床特征的综合元分析.
主要方法:
- 进行了系统的元分析.
- 搜索的数据库包括PubMed,Embase,科学网,科克兰图书馆,Scopus,万芳,CNKI,VIP和CBM.
- 分析了32项研究 (7758个结节) 的数据,使用Stata 16.0.0.
主要成果:
- 状体征,血管收,球状体征,气管支气管图,多叶膜引,边界模糊和真空体征与MSPN有显著的关联.
- 年龄较大,女性性别,结节直径较大,以及家族癌症史也会增加恶性瘤的风险.
- 与BSPN相比,在MSPN中观察到较低的化发生率.
结论:
- 状体标志,血管收,球状体标志,直径,边界模糊,真空体标志,年龄,性别,癌症家族病史,肺部引,气管支气管图标和化是固体肺结节 (SPN) 中恶性瘤的显著预测因素.
- 这些发现可以影响临床管理策略.
- 建议进行进一步的大规模研究以验证这些预测标记.
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