相关实验视频

Updated: May 26, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

在2型糖尿病中,循环中的基-1-酸盐和前体物种与冠状动脉化评分之间的反向关系

Wilfried Le Goff¹, Olivier Bourron^1,2, Clément Materne¹

¹INSERM, Foundation for Innovation in Cardiometabolism and Nutrition (ICAN), UMR_S1166, Sorbonne Université, 75013, Paris, France.

Cardiovascular diabetology

|February 21, 2025

概括

在2型糖尿病 (T2D) 患者中,神素1-酸盐 (S1P) 水平和前体与心血管疾病风险有关. 高密度脂蛋白 (HDL) 中较低的S1P与抗炎功能受损和较高的冠状动脉化 (CAC) 相相关.

科学领域:

脂质信号传递是什么
免疫学免疫学免疫学
心血管医学心血管医学

背景情况:

氨酸1-酸盐 (S1P) 是一种具有免疫调节和抗炎作用的脂质调解剂.
循环中的S1P和HDL-S1P与心血管疾病 (CVD) 风险相反相关.
在2型糖尿病 (T2D) 患者中S1P在心血管疾病风险中的作用仍然未被探索.

研究的目的:

调查循环S1P物种及其前体与T2D患者心血管疾病风险之间的关联.
确定S1P代谢的改变是否有助于T2D中心血管疾病风险的增加.

主要方法:

从T2D患者的血和HDL中量化S1P物种和前体的LC-MS/MS量化 (n=199).
在S1P水平和冠状动脉化 (CAC) 评分之间的相关性分析.
在S1P含量基础上对HDL抗炎性质的体外评估.

主要成果:

血S1P水平,特别是d18:1-S1P和HDL-sphingosine与T2D中高CAC得分 (>/=100) 相反相关.
具有高CAC分数的患者表现出S1P贫乏的HDL.
实验室研究表明,含有低S1P的HDL具有降低的抗炎能力.

结论:

循环中的S1P及其前体是T2D冠状动脉样硬化的潜在生物标志物.
降低S1P丰度和HDL抗炎活性受损可能导致T2D患者心血管疾病风险.

关键词:

动脉样硬化是一种动脉样硬化.心血管疾病的心血管疾病.高密度脂蛋白是一种高密度脂蛋白.斯芬哥辛-1-酸盐是一种酸盐.2 型糖尿病 2 型糖尿病

更多相关视频

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection

Published on: September 22, 2023

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

相关概念视频

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...

Inflammation

Inflammation

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...