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诊断时的营养状况及其与墨西哥急性淋巴细胞白血病儿童的生存和复发的关系:一项回顾性研究
Alan E Guzmán-León1, Sergio Gallegos-Castorena2, Hugo Romo-Rubio2
1Department of Chemical and Biological Sciences, Universidad de Sonora, Hermosillo, Sonora, Mexico.
BMC cancer
|February 21, 2025
概括
患有急性淋巴细胞白血病 (ALL) 的儿童的营养状况显著影响生存率和复发率. 营养不良儿童面临较差的结果,强调营养评估在ALL治疗的重要性.
科学领域:
- 儿科瘤学 儿科瘤学
- 临床营养学 临床营养学
- 流行病学 流行病学
背景情况:
- 儿童急性淋巴细胞白血病 (ALL) 在全球范围内表现出不同的生存率.
- 通过人体测量进行营养状况 (NS) 评估,以探索其与治疗结果的联系.
- 这项研究调查了墨西哥儿科ALL患者诊断时NS和复发/死亡率之间的关联.
研究的目的:
- 分析儿科ALL患者诊断时的营养状况与治疗结果 (复发/死亡率) 之间的关系.
- 评估人类指标作为预测者生存和复发在这个队列.
- 为儿童ALL营养状况的预后价值提供见解.
主要方法:
- 对252名儿科ALL患者进行了回顾性观察性研究.
- 使用人类指标 (Z-score) 评估NS,包括体重,身高,MUAC,TSF和SSF.
- 使用卡普兰-梅尔函数和考克斯回归模型来分析生存,复发和事件数据.
主要成果:
- 按BMI表示的营养不良与显著较低的存活率有关 (76%对63%,p=0.049).
- 在Triceps Skinfold (TSF) < -2 SD (41%对12%,p=0.007) 的患者中观察到更高的复发率.
- 衰退和低TSF增加了死亡风险,而更高的中上臂周长 (MUAC) Z-score降低了死亡风险.
结论:
- 通过人体测量评估的营养状况是儿科ALL患者存活和复发的重要预测因素.
- 人类测量测量为儿童ALL提供了有价值的预后信息.
- 早期的营养评估和干预可以改善儿科ALL患者的结果.
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