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膀体积变化对宫癌MR导向放射治疗中的剂量效应

Kaiwen Zhou^1,2, Cong Wang², Junfeng Zhao²

¹Department of Graduate, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, People's Republic of China.

|February 21, 2025

概括

膀体积的变化显著影响宫癌患者的辐射剂量分配. 监测膀填充量对于优化放射治疗计划和向临床目标体积 (CTV) 和有风险的器官 (OAR) 输送至关重要.

科学领域:

辐射瘤学辐射瘤学
医学物理医学物理
妇科瘤学妇科瘤学

背景情况:

放射治疗期间膀体积的波动会改变辐射剂量分配.
准确的剂量传递到目标体积和有风险的器官 (OAR) 在宫癌治疗中至关重要.
核磁共振指导放射治疗提供实时成像,用于适应性治疗计划.

研究的目的:

评估可变膀体积对临床目标体积 (CTV) 和OARs的剂量学影响.
为了评估接受MR指导放射治疗的宫癌患者的剂量分配变化.
了解膀填充如何影响治疗疗效和毒性.

主要方法:

对27名宫癌患者的回顾性分析,这些患者接受了MR指导放射治疗 (Elekta Unity MR-linac).
在前三次治疗的每日MRI图像上对CTV和OAR (膀,小肠,直肠,股骨头) 的轮.
使用摩纳哥TPS重新计算治疗计划,以评估膀体积变化的剂量效应.
使用SPSS来评估剂量测量变化的统计分析.

主要成果:

在术后放射治疗中,随着膀体积的增加,CTV剂量 (D98,D95) 减少.
在激光疗法中,CTV平均剂量增加,而膀最大剂量也随着膀填充而增加.
在术后组中,直肠和小肠剂量的影响较小,但在膀填充的激进组中,最低和平均剂量下降.

结论:

膀体积的变化对宫癌患者的CTV和OAR的剂量分配有显著的影响.
在MR指导放射治疗期间,每天进行MRI成像,可以评估这些体积和剂量变化.
考虑膀填充的适应性放射治疗策略可能是必要的,以优化治疗结果.

关键词:

适应性辐射疗法适应性辐射疗法膀的填充膀的填充宫癌是发生在宫癌的原因之一.每天的MR每天的MR 剂量分布剂量分布

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