通过转子子介导的Silurus鱼的性别染色体的起源,进化和转位
Shuqing Zheng1, Hongyan Tao1, Yuheng Song1
1Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), School of Life Sciences, Key Laboratory of Aquatic Science of Chongqing, Southwest University, Chongqing, 400715, China.
BMC biology
|February 21, 2025
概括
在Silurus鱼中,性染色体的进化揭示了性别决定基因和区域的频繁转换. 这种动态过程塑造了鱼类性染色体的多样性和同质性.
科学领域:
- 进化生物学 进化生物学
- 基因组学就是基因组学.
- 动物学 动物学
背景情况:
- 性染色体 (SC) 进化是进化生物学中的一个关键领域.
- 远程体显示性决定性 (SD) 基因和SCs的快速转换.
- 多种机制驱动鱼类中的SC分化.
研究的目的:
- 为了追踪Silurus属的性别染色体 (SCs) 的进化.
- 调查性别决定基因 (SD) 在SC进化中的作用.
- 了解驱动SC分化和鱼的营业额的机制.
主要方法:
- 染色体尺度组合的Silurus和外组物种. 外组物种.
- 对 amhr2y 基因的遗传学分析.
- 在男性特异性Y染色体区域 (MSYs) 中分析可移植元素活性和基因含量.
主要成果:
- SD基因 amhr2y起源于Silurus,Pterocryptis和Kryptopterus的分歧之前,并在后两种中消失了.
- Chr24 通过 LTR 转位子介导的 amhr2 复制和转位成为 Silurus 祖先的 SC.
- 男性特异性的Y染色体区域 (MSYs) 通过可移植元素扩张和基因招募进化,由于持续的TE积累,具有不同的大小 (320-550 kb).
- 发生了两个SC周转事件 (同源和非同源),可能由hAT和Helitron转位子介导.
结论:
- 在Silurus大鱼中, amhr2y,MSY和SC的动态演变突出了鱼类SC的变化和多样性.
- 频繁的SCs周转对于保持鱼类SCs的同质性和低差异性至关重要.
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