胰岛素抵抗 (METS-IR) 和高血压的代谢得分之间的关联:基于NHANES 2007-2018的横截面研究
Zhen Guo1, Xia Guo1, Hanchi Xu1
1Department of Cardiovascular Medicine, The First Hospital of Jilin University, Changchun, 130021, China.
Lipids in health and disease
|February 21, 2025
概括
胰岛素抵抗代谢评分 (METS-IR) 与高血压有着密切的联系. 较高的METS-IR分数表明患高血压的风险增加,突出其在代谢健康评估中的作用.
科学领域:
- 心血管健康 心血管健康
- 代谢综合征是代谢综合征的一种.
- 高血压研究 高血压研究
背景情况:
- 胰岛素抵抗 (IR) 损害了胰岛素的有效性,并增加了包括高血压在内的心血管疾病风险.
- 胰岛素抵抗的代谢评分 (METS-IR) 提供了一种简化的评估 IR 使用甘油三 (TG),高密度脂蛋白胆固醇 (HDL-C),体重指数 (BMI) 和禁食葡萄糖.
- 高血压患病率的增加,特别是在代谢障碍中,需要了解与METS-IR.的联系.
研究的目的:
- 调查胰岛素抵抗代谢评分 (METS-IR) 与高血压之间的关联.
- 确定METS-IR是否可以作为大量人群中高血压风险的早期指标.
- 通过考虑各种人口和临床因素来分析这种关系.
主要方法:
- 利用了国家健康和营养检查调查 (2007-2018) 的16310名参与者的数据.
- 通过自我报告和血压测量来确定高血压.
- 使用ln([HDL-C] × [2 × 禁食葡萄糖] + [TG] × [BMI]计算METS-IR,并使用多因素回归模型对许多共变量进行调整.
主要成果:
- 在METS-IR和高血压之间发现了显著的正相关性.
- 每增加1个单位的METS-IR与高血压的几率增加3%有关 (OR,1.03;95% CI,1.03-1.04).
- 模型3显示了一个显著的联系 (OR,3.31;95% CI,2.64-4.14;P < 0.001),通过值效应分析确定了一个非线性关联. 小组分析证实了关系的稳定性.
结论:
- METS-IR显示了与高血压的强有力的关联.
- METS-IR可以作为评估代谢健康和预测早期高血压风险的宝贵生物标志物.
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