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刺激性肠综合征发展的危险因素:综合评论的系统性综合审查
Farisah Sulaimi1, Timothy Sheng Khai Ong2, Ansel Shao Pin Tang2
1School of Medical Sciences, Wallace Wurth Building, University of New South Wales, Sydney, NSW, Australia.
本综述巩固了有关易肠综合征 (IBS) 风险因素的证据. 女性性别,焦虑,抑郁和胃肠炎是关键因素,尽管评论质量往往很低.
科学领域:
- 胃肠病学和内科医学
- 流行病学 流行病学
- 精神病学是一个精神病学.
背景情况:
- 刺激性肠综合征 (IBS) 影响全球4-9%,呈现复杂的,多因素的原因.
- 本综述综合了有关IBS遗传,免疫,心理和饮食风险因素的证据.
- 这项研究协议以PROSPERO CRD42023493739.9号注册.
研究的目的:
- 巩固现有的证据,关于风险因素,有助于刺激性肠综合征 (IBS) 的发展.
- 对IBS的潜在遗传,免疫,心理和饮食原因进行系统审查和元分析.
- 基于全面的文献综合,确定IBS的关键风险因素.
主要方法:
- 在MEDLINE,Embase和Cochrane图书馆数据库中进行了系统的文献搜索.
- 包括69项系统审查,使用AMSTAR 2评估其质量,使用GRADE方法论评估证据.
- 从检查IBS风险因素的合格系统审查中进行叙述性综合的结果.
主要成果:
- 大多数包括的系统性审查的质量"非常低"或"低",方法上存在缺陷.
- 确定了八大类型的IBS风险因素:饮食,遗传,环境,心理,肠道微生物组,社会经济,生理和病理.
- 最常见的风险因素包括女性性别和焦虑症 (GRADE"低");抑郁症和胃肠炎 (GRADE"中等").
结论:
- 临床实践应强调识别IBS风险因素.
- 未来的系统审查需要提高报告质量,遵守PRISMA指南.
- 提高研究报告的质量对于进一步了解IBS病因至关重要.
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