在预防术后狂妄症方面,经手术期间的雷米马佐拉姆的有效性:系统性审查和元分析
Mingzhen Wang1,2, Jinhui Liu2, Wenjie Liu2
1School of Anesthesiology, Shandong Second Medical University, No. 5 Donghai Middle Road, Qingdao, 266071, China.
在外科手术期间使用雷米马佐拉姆可以降低非心脏手术患者手术后 Delirium (POD) 的风险. 然而,与德克斯米德米丁或普罗波相比,它在POD率上没有显著差异.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 关键护理医学 关键护理医学
背景情况:
- 手术后痴呆症 (POD) 在接受非心脏手术的患者中是一个重大问题.
- 评估术后镇静剂对于优化患者的治疗结果至关重要.
研究的目的:
- 为了比较在非心脏手术期间接受雷米扎洛拉姆治疗的患者与安慰剂或其他镇静剂的术后狂妄症 (POD) 的发生率.
- 评估雷米马佐拉姆的安全性,包括低血压,心肌梗塞和恶心/吐的风险.
主要方法:
- 在四个主要数据库 (Cochrane,Web of Science,Embase,PubMed) 系统搜索随机对照试验 (RCT).
- 包含了11个RCT,其中有1985名参与者.
- 主要结局:术后妄想 (POD). 二次结局:低血压,心,恶心和吐.
主要成果:
- 与盐溶液安慰剂相比,雷米马佐拉姆显著降低了70%的POD风险 (RR 0.30).
- 在雷米马佐拉姆,德克斯梅托米丁 (RR 1.23) 或普罗波 (RR 0.83) 之间没有观察到POD风险的显著差异.
- 与德克斯梅托米丁 (RR 0.25) 和普罗波福尔 (RR 0.45) 相比,雷米扎洛兰显著降低了低血压风险,在肌心病或恶心/吐方面没有显著差异.
结论:
- 在非心脏外科手术中,术后使用雷马佐拉姆与术后狂妄症的风险较低有关.
- 雷米马佐拉姆在预防POD方面并不优于德克斯梅德托米丁或普罗波.
- 雷米马佐拉姆在预防手术内低血压方面具有优势,与德克斯米德米丁和普罗波相比.
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