环境污染物SO2暴露会影响热囊细胞功能,涉及ER应力路径
Sunil Singh1, Isha Goel2, Javed Ahsan Quadri3
1Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
The Journal of physiology
|February 22, 2025
概括
暴露于二氧化硫 (SO2) 损害了胎盘发育,因为它损害了热囊细胞的入侵和融合. 这种有毒的空气污染物会诱导细胞内网膜应激和表观遗传变化,可能导致不良妊娠结果.
科学领域:
- 环境健康 环境健康
- 生殖生物学 生殖生物学
- 毒理学 毒理学 毒理学
背景情况:
- 二氧化硫 (SO2) 是一种有毒的空气污染物,影响多个器官系统.
- SO2可以穿过胎盘,对胎儿发育构成风险.
- 以前的研究将SO2暴露与不良妊娠结果联系起来,但分子机制尚不清楚.
研究的目的:
- 研究SO2衍生物对胎过程中必不可少的关键 trofhoblast 功能的分子作用.
- 检查SO2对热囊细胞入侵,融合,迁移和分化的影响.
- 阐明SO2诱导的胎盘功能障碍背后的细胞和表观遗传机制.
主要方法:
- 利用BeWo和HTR8/SVneo细胞系来建模 trofhoblast 功能.
- 评估了SO2衍生物暴露后的热囊细胞入侵,迁移和融合潜力.
- 分析了分子变化,包括内质网膜应激和组织蛋白修饰.
主要成果:
- 暴露于SO2显著抑制了BeWo细胞的融合潜力.
- 热囊细胞的入侵和HTR8/SVneo细胞的迁移能力受到SO2的影响.
- 分子分析揭示了SO2诱导的细胞内网膜应激和改变的基因组修饰.
结论:
- SO2衍生物对关键的热囊细胞功能有不利影响,包括迁移,入侵和融合.
- 暴露于SO2会破坏热囊细胞的相互作用和组织.
- 从机制上讲,SO2会诱导内质网膜应激和炎症,改变表观遗传标记,从而损害胎盘功能,并可能导致不良妊娠结果.
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