低剂量雌激醇的跨性别女性早期身体组成变化:使用双重能量吸收度和生物电阻分析比较口服和舌下给药:使用双重能量吸收度和生物电阻分析比较口服和舌下给药
Iris Yaish1,2, Assaf Buch3,1, Guy Gindis1,2
1Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
The journal of sexual medicine
|February 22, 2025
概括
在性别肯定激素治疗 (GAHT) 中低剂量的雌激素在六个月内显著改变了跨性别女性的身体组成. 在管理脂肪积累方面,与口服相比,下语言雌醇可能具有优势.
科学领域:
- 内分泌学 在内分泌学.
- 跨性别者健康 跨性别者健康
- 身体组成分析 身体成分分析
背景情况:
- 低剂量的语言下雌激素是有效的抑制和乳腺发育在跨性别女性.
- 它在性别肯定激素治疗 (GAHT) 期间对身体组成的影响尚未得到充分研究.
研究的目的:
- 在GAHT上评估跨性别女性早期的身体组成变化.
- 进行比较,以语言下和口服 Estradiol 进行管理.
- 评估生物电阻分析 (BIA) 和双能X射线吸收计 (DXA) 之间的一致性.
主要方法:
- 对22名未经治疗的跨性别女性进行了为期6个月的前性研究.
- 这些组接受了每天2毫克的舌下雌激素 (SLE) 或口服 (CO) 雌激素与cyproterone acetate的联合治疗.
- 在基线和6个月时通过DXA和BIA评估的身体组成.
主要成果:
- 两组人都显示瘦身量下降,脂肪量增加.
- 与口服组相比,下舌 Estradiol 组的总和内脏脂肪增加较小.
- 这两种治疗都降低了腰部至部和安卓至骨脂肪的比率,这表明女性化.
结论:
- 低剂量雌激素诱导女性化身体组成的变化在GAHT的6个月内.
- 舌下雌激醇可以帮助限制脂肪积累,同时促进女性的身体形状.
- 结果可以为GAHT协议的优化和结果监测提供信息.
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