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在使用索福斯布维尔和韦尔帕塔斯维尔治疗后的双边神经网膜炎
Hitesh Sharma1, Jaydeep Walinjkar2, Parthopratim Dutta Majumder3
1Uvea Services, Agarwal Eye Hospital, Mumbai, India.
Ocular immunology and inflammation
|February 22, 2025
概括
直接作用的抗病毒药物 (DAA),如索福斯布维尔和韦尔帕塔斯维尔,可导致慢性肝炎C治疗患者的神经网膜炎类症状. 症状在停止服用药物后消失,突出需要考虑眼部副作用.
科学领域:
- 眼科医生 眼科 眼科
- 肝病学 肝病学是一种肝病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 直接作用抗病毒药物 (DAA) 是对慢性肝炎C感染的高度有效治疗方法.
- 与DAA相关的眼部副作用尚未完全理解.
- 这一案例突出了DAA治疗的潜在神经眼科并发症.
研究的目的:
- 在接受直接作用抗病毒药物 (DAA) 治疗后报告双边神经网膜炎样呈现的病例.
- 调查索福斯布维尔和韦尔帕塔斯维尔治疗与视觉障碍之间的潜在联系.
- 提高人们对与C型肝炎治疗相关的潜在眼部不良事件的认识.
主要方法:
- 一个追溯的观察案例报告.
- 关于DAA相关眼部副作用的相关医学文献的综述.
- 临床检查和诊断工作以排除视力障碍的其他原因.
主要成果:
- 一名49岁的男性接受了针对C型肝炎的sophisbuvir和velpatasvir治疗,患有双边无痛视力损失.
- 两只眼睛都观察到类似神经网膜炎的变化.
- 在停止服用DAA并排除其他病因后,症状完全消失.
结论:
- 在接受慢性肝炎C的DAA治疗的患者中,应考虑眼部副作用,包括神经视网膜炎样图片.
- 这些发现强调了在DAA治疗期间监测视力健康的重要性.
- 需要进一步的研究来阐明DAA诱导的眼睛毒性的机制和发病率.
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