在代谢综合征的背景下,转移性乳腺癌中母细胞蛋白的表达模式
A D Neborets1,2, S I Nikolayenko3, I I Smolanka2
1R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine.
Experimental oncology
|February 22, 2025
概括
代谢综合征在原发性转移性乳腺癌 (mBCa) 中改变了骨质素和骨质素的表达,这表明这些蛋白质可以预测受影响的绝经后妇女的疾病过程.
科学领域:
- 在瘤学瘤学.
- 生物化学 生物化学
- 代谢综合征研究 代谢综合征研究
背景情况:
- 转移性乳腺癌 (mBCa) 是绝经后妇女的主要死亡原因.
- 骨基质重塑蛋白显示出预测乳腺癌 (BC) 进展的潜力.
- 了解代谢综合征 (MetS) 的mBCa中的蛋白质表达是至关重要的.
研究的目的:
- 为了研究骨质素 (OPN) 和骨质素 (ON) 在初级mBCa (pmBCa) 瘤组织中的表达之间的关系.
- 在有或没有代谢综合征 (MetS) 的更年期患者中分析这些关系.
- 为了将蛋白质表达与pmBCa.的临床病理特征相关联.
主要方法:
- 该研究包括54名患有pmBCa的更年期患者;23人患有MetS,31人没有.
- 免疫组织化学被用来确定OPN和ON表达水平.
- 与蛋白质表达相关的临床病理特征被分析.
主要成果:
- 在N3 pmBCa的MetS患者中,OPN表达增加 (H-Score 265.6 ± 7.7) 和ON减少 (H-Score 123.2 ± 7.7).
- 与MetS一起的侵入性叶状pmBCa显示了OPN的降低 (H-Score 219.4 ± 8.4) 和增加的ON (H-Score 144.8 ± 7.5).
- MetS患者在光线A,B和Her2/neu亚型以及肝转移病例中表现出减少的ON表达.
结论:
- 在pmBCa组织中的OPN和ON表达水平与恶性瘤程度相关.
- 这些发现突显了pmBCa MetS患者OPN和ON的预后潜力.
- 进一步的研究是有必要的,以探索这些蛋白质在MetS的背景下预后价值.
相关概念视频
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
The Tumor Microenvironment
6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K


