更多的酒精摄入预测了人类加速的大脑衰老,这介绍了酒精摄入量和行为不灵活性之间的关系
Jillian T Battista1, Elena Vidrascu1,2, Madeline M Robertson1
1Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Alcohol, clinical & experimental research
|February 22, 2025
概括
危险的酒精使用加速大脑衰老,即使在年轻人中也是如此. 这种加速的大脑衰老调解了饮酒和行为灵活性受损之间的联系.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 危险的酒精使用与认知缺陷和加速衰老有关.
- 加快大脑衰老作为酒精使用和行为不灵活之间的调解者的作用仍未得到充分研究.
- 这项研究调查了危险的酒精使用作为机器学习衍生的大脑衰老的预测因素.
研究的目的:
- 为了评估危险的酒精使用作为机器学习估计的大脑年龄的预测因素.
- 为了确定大脑年龄是否介导酒精使用和行为不灵活之间的关系.
- 检查酒精消费与年轻成年人的行为缺陷之间的关联.
主要方法:
- 将 brainageR机器学习算法应用于健康成年人 (年龄22-40岁) 的T1加权MRI扫描.
- 通过酒精使用障碍识别测试 (AUDIT) 评估酒精使用,并使用隐藏图像之间的关联任务 (HABIT) 评估行为灵活性.
- 在 HABIT 上量化行为不灵活性作为坚持性错误,并进行调解分析.
主要成果:
- 较高的AUDIT分数显著预测了加速的大脑衰老,独立于年代和性别.
- 加快的大脑衰老与习惯的坚持性错误增加有关,这表明行为不灵活性更大.
- 大脑衰老显著介导了AUDIT分数和行为不灵活之间的关系.
结论:
- 酒精使用预测加速大脑衰老,即使在年轻成年时也是如此.
- 大脑衰老可能是危险的酒精使用和行为灵活性受损之间的机械联系.
- 未来的研究应该探索可能减轻酒精和年龄相关的大脑变化的生活方式因素.
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