在具有FFR/iFR不一致性的船只中,通过拉回压力梯度指数评估的生理疾病模式
Pruthvi C Revaiah1, Tsung-Ying Tsai1, Albert Chinhenzva1
1CORRIB Research Centre for Advanced Imaging and Core Laboratory, University of Galway, Galway, Ireland.
JACC. Cardiovascular interventions
|February 22, 2025
概括
冠状动脉疾病 (CAD) 的生理模式影响了分量流量储备 (FFR) 和即时无波比 (iFR) 之间的差异. 拉回压力梯度指数 (PPGi) 有助于在不一致的情况下区分焦点与分散的CAD模式.
科学领域:
- 心血管医学 心血管医学
- 干预心脏病学 干预心脏病学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 分流储备 (FFR) 和即时无波比 (iFR) 在大约20%的冠状动脉疾病 (CAD) 病例中显示出不一致.
- CAD的生理模式,以拉回压力梯度指数 (PPGi) 为特征,可能解释这些差异.
研究的目的:
- 调查拉回压梯度指数 (PPGi) 是否在不一致的分流储备 (FFR) 和即时无波比 (iFR) 组 (FFR+/iFR- vs. FFR-/iFR+) 之间有所不同.
- 评估CAD生理模式在FFR/iFR异调中的作用.
主要方法:
- 355名患有慢性冠状动脉综合征和中等心上冠状动脉病变的患者接受了侵入性冠状动脉血管学,FFR,iFR和PPGi分析.
- 血管根据FFR (≤0.80) 和iFR (≤0.89) 显著性和PPGi (≥0.75用于焦点,<0.75用于扩散) 模式进行分类.
主要成果:
- 在16.7%的案例中,FFR和iFR不同意.
- 与FFR+/iFR-组 (焦点CAD) 相比,FFR-/iFR+组 (扩散CAD) 的PPGi中位数显著较低 (0.65对0.82;P<0.001).
- 主要焦点CAD与FFR+/iFR- (76.3%) 相关,而扩散CAD与FFR-/iFR+ (96.3%) 相关.
结论:
- 冠状动脉疾病 (CAD) 的生理模式,根据PPGi的评估,是导致FFR和iFR之间不一致的重要因素.
- 了解CAD模式可以帮助解释FFR/iFR差异.
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