在四个前性,多中心,随机 ABCSG 试验中验证 CTS5
Kerstin Wimmer1, Dominik Hlauschek2, Marija Balic3
1Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria; Austrian Breast & Colorectal Cancer Study Group, Vienna, Austria; Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Breast (Edinburgh, Scotland)
|February 22, 2025
概括
5年后的临床治疗评分 (CTS5) 有效地分层了激素受体阳性乳腺癌晚期远程复发的风险. 然而,它预测延长内分泌治疗的益处的能力是不确定的.
科学领域:
- 在瘤学瘤学.
- 临床医学 临床医学
- 生物统计学 生物统计学
背景情况:
- 5年后的临床治疗评分 (CTS5) 是一种工具,用于在辅助内分泌治疗 (ET) 后估计激素受体阳性 (HR +) 乳腺癌患者的晚期远程复发 (LDR).
- 对于指导延长ET的CTS5的预后价值尚未得到充分确立.
研究的目的:
- 评估CTS5在HR+乳腺癌患者的预后能力,校准准确度和预测价值.
- 评估CTS5在识别可能从延长内分泌治疗中受益的患者中的实用性.
主要方法:
- 利用了来自四项前性随机 ABCSG 试验 (ABCSG-6, -6a, -8 和 -16) 的 4931 名患者的数据,其中包括 250 个 LDR 事件.
- 使用考克斯回归模型计算CTS5分数并分析到LDR的时间,以评估预后和预测能力.
主要成果:
- CTS5显示出预后价值,较高的得分与HR+乳腺癌中LDR风险增加有关.
- 评分显示LDR风险略高估计,但确定了高风险患者.
- 虽然没有发现ET延长的显著相对预测值,但在具有延长ET的高CTS5患者中观察到23.4%的绝对LDR风险降低.
结论:
- CTS5是一种经过验证的工具,用于对HR+乳腺癌中LDR风险进行分层.
- 建议在使用CTS5来确定延长内分泌治疗的益处时谨慎使用,因为预测价值不确定.
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