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相关概念视频

Caspases01:24

Caspases

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Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
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The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.0K
Apoptosis01:30

Apoptosis

10.6K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
10.6K
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

5.9K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
5.9K
Overview of Cell Death01:30

Overview of Cell Death

6.4K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
6.4K
Autophagic Cell Death01:18

Autophagic Cell Death

3.0K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
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相关实验视频

Updated: May 26, 2025

Evaluation of Caspase Activation to Assess Innate Immune Cell Death
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Evaluation of Caspase Activation to Assess Innate Immune Cell Death

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在PANoptosis中的卡斯帕斯.

Kaiyuan Song1, Yongbin Wu1, Sipin Tan1

  • 1Department of Pathophysiology, Xiangya School of Basic Medicine Science, Central South University, Changsha, PR China; Sepsis Translational Medicine Key Laboratory of Hunan Province, Central South University, Changsha, PR China; National Medicine Functional Experimental Teaching Center, Central South University, Changsha, PR China.

Current research in translational medicine
|February 22, 2025
PubMed
概括
此摘要是机器生成的。

调节的细胞死亡途径,如热亡,细胞亡和亡广泛交叉. 新的炎症性细胞死亡途径PANoptosis集成了这些途径的特征,并涉及caspases,提供新的治疗点.

关键词:
这就是PANoptosis.卡斯帕-6是一种在Caspase-8中使用.

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Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation
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科学领域:

  • 细胞生物学 细胞生物学
  • 免疫学 免疫学 免疫学
  • 分子生物学分子生物学

背景情况:

  • 已知有三个主要的受调细胞死亡 (RCD) 途径 - - 细胞亡,细胞亡和细胞亡 - - 相互作用.
  • PANoptosis是最近发现的一种RCD途径,它结合了apoptosis,pyroptosis和necroptosis的特征.
  • 酶,关键的氨酸蛋白酶,参与了亡,烧亡和亡.

研究的目的:

  • 为了审查apoptosis,pyroptosis和necroptosis的分子机制和交叉声.
  • 探索PANoptosis的发现和疾病关联.
  • 讨论caspases,特别是caspase-6和caspase-8在PANoptosis中的作用.

主要方法:

  • 在RCD中的分子机制的文献综述.
  • 分析火灭亡,光灭亡和死灭亡之间的交叉语音.
  • 关于PANoptosis发现,疾病联系和caspase参与的研究的审查.

主要成果:

  • 已建立的RCD路径显示出显著的交叉通话.
  • PANoptosis 整合了 apoptosis, pyroptosis 和 necroptosis 的特征,其中包括 caspases.
  • 卡斯帕-6和卡斯帕-8是PANoptosis中的关键分子.

结论:

  • 了解RCD交叉声和PANoptosis对于疾病干预至关重要.
  • 卡斯帕斯在PANoptosis中发挥着中心作用.
  • 这一综述为针对疾病中的PANoptosis提供了基础.