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在周围动脉疾病中的营养L-Citrulline和Tetrahydrobiopterin:第二阶段随机试验 (CIPER研究)
Daniel Sedding1, Tim M Schmidt2, Heike Bähre3
1Klinik für Kardiologie, Universitätsklinikum Halle, Halle, Germany; Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany.
在外周动脉疾病 (PAD) 患者中,补充L-氨酸显著改善了步行距离. 添加四生物素 (H4Bip) 进一步增强了益处,特别是在具有高ADMA水平的人群中.
科学领域:
- 心血管研究研究心血管研究
- 营养科学 营养科学
- 血管生物学 血管生物学
背景情况:
- 周围动脉疾病 (PAD) 是一个重大的公共卫生挑战,药物治疗的有效性有限.
- 目前针对PAD的干预措施的有效性各不相同,对于一些药物来说,需要治疗的药物数量很高.
研究的目的:
- 为了评估L-素和四二二 (H4Bip) 对PAD患者的步行距离的影响.
- 根据不对称的二甲基L-氨酸 (ADMA) 的血水平来分层治疗效果,这是一种氧化合成酶的抑制剂.
主要方法:
- 一个随机的,安慰剂控制的,双盲交叉试验,涉及51名PAD患者.
- 在12周的L-素 (3g BID) 和另外2周的H4Bip (0.45g QD) 后,评估绝对音距离 (dACD) 的变化.
- 测量了介入前的ADMA水平,以分层患者群体.
主要成果:
- 与安慰剂相比,L-氨酸补充剂显著增加了血L-氨酸和L-氨酸水平.
- 氨酸改善了DACD的20.11%,与安慰剂5.73%相比 (P=0.011).
- 在患有病理性ADMA水平的患者中,添加H4Bip进一步增加了28.15%的DACD (P=0.021).
结论:
- 氨酸作为一种有效的营养干预措施,可以改善PAD患者的行走能力.
- 水生物素 (H4Bip) 在患有ADMA水平升高的PAD患者中提供了额外的益处.
- 需要进一步的试验来证实这些发现对于PAD管理.
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