构成丸发育变异的分子机制,是天福诺华的不同品种之间的分子机制
Shenqiang Hu1, Yang Song1, Jiaran Zhu1
1State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China; Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China; Key Laboratory of Agricultural Bioinformatics, Ministry of Education, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China.
雄的丸发育因遗传线而异,GF1显示出更快的生长和更高的丸水平. 这些差异与基因表达有关,影响生殖性能.
科学领域:
- 禽畜科学 禽畜科学 禽畜科学
- 生殖生物学 生殖生物学
- 分子内分泌学分子内分泌学
背景情况:
- 男的生殖和经济表现取决于丸的发育和精液质量.
- 了解子丸发育机制是有限的,先前的研究重点是环境因素或单一品种.
研究的目的:
- 在三个子系中全面分析丸组织形态学,血清丸激素和HPT轴基因表达的年龄相关变异.
- 阐明子丸发育的变化背后的分子机制.
主要方法:
- 在化后的24周内,研究了来自三个品系 (GF1,BGF2,MC) 的240只天府诺华雄.
- 分析了丸组织结构学,血清丸激素 (T),以及与下丘脑-垂体-丸 (HPT) 轴相关的基因的表达.
- 与丸水平和丸器官指数相关的基因表达.
主要成果:
- 丸发育依赖于年龄和遗传系;GF1显示双边丸器官指数 (BTOI) 高,初级精子细胞出现较早.
- 血清T水平在8至16周之间达到峰值,GF1始终高于BGF2.
- 脑下垂体GNRH-I和垂体LHβ表达在GF1中较高,而丸CYP17A1在BGF2中较高,与T水平和BTOI正相关.
结论:
- GF1子丸的发育速度快于MC和BGF2线,这是由于血清T水平较高.
- 年龄相关的丸CYP17A1表达特征与观察到的丸水平变化有很强的关联.
- 研究结果提供了关于子丸发育和生殖潜力的分子机制的见解.
相关概念视频
Background and Environment Affect Phenotype
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Complementation Tests
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
The Y Chromosome Determines Maleness
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
Development of the Sexual Organs in the Embryo and Fetus
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
Dosage Compensation
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon...


