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Updated: May 1, 2026

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暴露在环境中的微塑料颗粒的细胞内化途径:花细胞形成或巨细胞形成?

Anja F R M Ramsperger¹, Simon Wieland¹, Magdalena V Wilde²

¹Animal Ecology I and BayCEER, University of Bayreuth, Bayreuth, Germany; Biological Physics, University of Bayreuth, Bayreuth, Germany.

Journal of hazardous materials

|February 22, 2025

概括

微塑料颗粒在淡水和盐水中形成独特的蛋白质生态冠状. 这些生态冠状体影响细胞对微塑料的内部化,每个环境来源都观察到不同的机制.

科学领域:

环境科学环境科学
细胞生物学细胞生物学
毒理学毒理学毒理学

背景情况:

微塑料颗粒 (MP) 是无处不在的环境污染物.
MP与生物分子相互作用,形成一个生态冠冕,改变它们的表面特性和细胞相互作用.
生态冠状病毒中的蛋白质可能会调解MP与细胞膜受体的相互作用.

研究的目的:

调查不同环境介质 (淡水与盐水) 的生态冠状病毒是否具有不同的蛋白质组成.
确定这些独特的生态冠状病毒是否影响MP细胞相互作用,特别是内部化效率和机制.
阐明生态冠状病毒起源在微塑料细胞吸收中的作用.

主要方法:

在淡水 (FW) 和盐水 (SW) 环境中的微塑料颗粒上形成生态冠状病毒.
对FW和SW衍生的生态冠状病毒中蛋白质组成差异的分析.
评估微塑料颗粒对细胞的粘附.
评估微塑料颗粒内部化效率和使用抑制剂的机制,如cytochalasin-D,Amiloride和Amantadine.

主要成果:

在FW和SW形成的生态冠状病毒中观察到不同的蛋白质组成.
在MP与FW或SW-eco-coronae之间没有发现粘附强度的显著差异.
观察到内部化效率和机制的显著差异:FW生态冠状病毒有利于细胞,而SW生态冠状病毒更容易与巨细胞结合.

结论:

生态冠状病毒的环境起源显著影响了微塑料颗粒的细胞内化途径.
了解生态冠状病毒的组成对于预测微塑料的生物影响和毒理影响至关重要.
这些发现强调了在评估微塑料对水生生物和生态系统构成的风险时考虑生态冠状病毒的重要性.

关键词:

细胞内部化的细胞内部化.生态冠状病毒巨型皮诺细胞形成症微流体学微流体学微塑料是一种微塑料.光学子是一种光学子.发细胞症 (phagocytosis) 是一种致死细胞的发生.蛋白质组学是指蛋白质组学.

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