有机酸在怀孕期间对甲状腺功能的影响:怀孕早期和中期内分泌干扰剂的风险
Yang Li1, YouRong Fu1, Xing Liao2
1Department of Blood Transfusion, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Journal of environmental management
|February 22, 2025
概括
有机酸 (OPEs) 可能会破坏母亲的甲状腺激素 (THs),特别是在怀孕早期. 像TNBP和TCIPP这样的特定OPE显示与甲状腺功能标记物的关联,这表明潜在的干扰与下丘脑-垂体-甲状腺 (HPT) 轴.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 有机酸 (OPE) 是广泛使用的阻燃剂和增塑剂.
- 以前的研究表明,OPE可以干扰甲状腺激素 (TH) 功能.
- 有限的研究存在于怀孕期间各种OPEs和孕产妇THs之间的特定关联.
研究的目的:
- 调查暴露于特定的OPE与母亲甲状腺激素水平之间的关联.
- 探索OPE在不同怀孕阶段对下丘脑-垂体-甲状腺 (HPT) 轴的潜在干扰.
- 检查TPOAb地位对OPE-TH协会的影响.
主要方法:
- 研究人口分为怀孕早期和怀孕中期的组.
- 对特定OPE代谢物 (TNBP,TCIPP,TCEP,EHDPP,TEHP,TMPP) 和THs (TSH,FT4,FT3) 之间的相关性进行分析.
- 限制立方线分析以评估剂量反应关系和HPT轴恒温指标 (TSH/FT4比率).
主要成果:
- 在所有怀孕组中,TNBP和TCIPP与TSH正相关;TCEP与FT4/FT3比率正相关.
- 在怀孕早期,EHDPP和TEHP与FT3和FT4相关;TNBP与TSH相关,TEHP与FT4/FT3相关.
- 协会经常表现出L形关系,特别是TNBP和TCIPP与HPT轴标记器,但整体OPE影响并不显著.
结论:
- 某些OPE,如TNBP和TCIPP,可能会破坏母体甲状腺激素稳定,并干扰HPT轴,特别是在怀孕早期.
- OPEs对甲状腺功能的影响在怀孕期间可能是特定阶段的.
- 需要进一步的人类研究来阐明OPE诱导的甲状腺功能障碍的机制.
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