癌症患者口服营养补充剂:系统性审查和剂量反应元分析
Sajedeh Habibi1, Sepide Talebi2, Darya Khosravinia3
1Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Clinical nutrition (Edinburgh, Scotland)
|February 22, 2025
概括
口服营养补充剂 (ONS) 显著改善生活质量,减少疲劳,并促进癌症患者接受化疗的体重增加. 需要进一步的研究来证实这些益处,并探索最佳的ONS剂量.
科学领域:
- 在瘤学瘤学.
- 临床营养学 临床营养学
- 基于证据的医学基于证据的医学.
背景情况:
- 接受化疗的癌症患者经常经历营养不良和与治疗相关的副作用.
- 口服营养补充剂 (ONS) 用于支持营养状况和管理这些患者的症状.
- 对ONS对各种临床结果的确切影响需要进行系统的评估.
研究的目的:
- 进行随机临床试验 (RCT) 的系统审查和剂量反应元分析.
- 确定ONS对癌症患者的体重,BMI,血清白蛋白,疲劳,生活质量 (QOL),PG-SGA和CRP的影响.
- 调查ONS摄入量和关键患者结局之间的剂量反应关系.
主要方法:
- 在PubMed,Scopus和Web of Science进行了系统的文献搜索,截至2024年4月.
- 纳入随机临床试验 (RCT),评估在接受化疗,放射治疗的癌症患者中的ONS.
- 使用随机效应模型进行的对照和剂量反应元分析.
主要成果:
- 经过ONS的管理,体重增加显著改善 (1.18公斤),减少疲劳 (SMD:-1.45),并提高了QOL (SMD: 1.38).
- 剂量反应分析显示,随着ONS剂量增加,疲劳和QOL显著改善 (白蛋白每天≥200毫升,疲劳每天≥400毫升,QOL每天≥500毫升).
- 在对对的元分析中,没有观察到对BMI,血清白蛋白,CRP或PG-SGA得分的显著影响.
结论:
- 口服营养补充剂 (ONS) 在改善生活质量,减少疲劳和促进癌症患者体重增加方面具有显著的益处.
- 对于ONS,存在剂量依赖的关系,较高的摄入量与疲劳和QOL的更大改善有关.
- 虽然ONS显示出前景,但需要进一步的高质量研究来巩固研究结果并优化治疗策略.
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