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Updated: May 26, 2025

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提奥斯特普顿通过FOXM1-介导的与瘤相关的巨细胞重编程来抑制肝内胆管癌的进展

Yu Li1, Yifan Jiang1, Rongliang Tong1

  • 1Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, PR China; NHC Key Laboratory of Combined Multi-organ Transplantation, Hangzhou, 310003, PR China; Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, Research Unit of Collaborative Diagnosis and Treatment for Hepatobiliary and Pancreatic Cancer, Chinese Academy of Medical Sciences, Hangzhou, 310003, PR China; Key Laboratory of Organ Transplantation, Zhejiang province, Hangzhou, 310003, PR China.

Translational oncology
|February 22, 2025
PubMed
概括

提奥斯特 (TST) 通过抑制 Forkhead box M1 (FOXM1) 来表现出对肝内胆管癌 (ICC) 的双重抗瘤作用. 通过重编程巨细胞,TST抑制了ICC的生长,并通过重编程巨细胞增强了抗瘤免疫力,提供了一个有前途的新免疫疗法策略.

关键词:
叉头盒 M1 叉头盒免疫治疗是一种免疫疗法.在肝脏内发生的胆管癌,胆管癌.这里是Thiostrepton.与瘤相关的巨细胞.

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