皮质醇在精神分裂症谱系障碍:一个全面的元分析
Lydia Kogler1, Rui Wang2, Teresa Luther3
1Department of Psychiatry and Psychotherapy, Tübingen Centre for Mental Health (TüCMH), Medical Faculty, University of Tübingen, Calwerstrasse 14, 72076 Tübingen, Germany; German Center for Mental Health (DZPG) Partner Site Tübingen 72076 Tübingen, Germany.
Frontiers in neuroendocrinology
|February 22, 2025
概括
抗精神病治疗降低了皮质醇在精神分裂症谱系障碍 (SSD). 与健康对照人群相比,SSD患者的皮质醇水平发生变化,特别是早上和晚上基线皮质醇升高,德甲后抑制减少.
科学领域:
- 神经内分泌学神经内分泌学
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 精神分裂症谱系障碍 (SSD) 与下丘脑-垂体-上腺 (HPA) 轴的失调有关,由改变的皮质醇水平证明.
- 抗精神病药物是SSD的主要治疗方法,可能会影响HPA轴活动和皮质醇概况.
- 了解SSD中的皮质醇动态对于阐明疾病机制和治疗效果至关重要.
研究的目的:
- 在精神分裂症谱系障碍 (SSD) 患者中对皮质醇变化的综合元分析.
- 评估抗精神病治疗对SSD患者皮质醇水平的影响.
- 在SSD患者和健康对照者 (HC) 之间比较皮质醇参数 (基线,应激反应能力,头发皮质醇,德甲抑制).
主要方法:
- 在PubMed,Web of Science和PsycINFO进行了系统的文献搜索,直到2024年11月.
- 对121项研究的数据进行了元分析,其中包括9049名SSD患者.
- 对皮质醇水平进行了分析,涉及抗精神病治疗效应,压力反应,头发皮质醇和SSD与HC的基线日间变化.
主要成果:
- 抗精神病治疗显著降低了SSD患者的皮质醇水平 (g = -0.480,p = 0.005).
- 与HC相比,SSD患者的皮质醇抑制在甲 (g = 0.299,p = 0.005) 和升高的早晨 (g = 0.38,p < 0.001) 和晚上 (g = 0.368,p = 0.014) 基线皮质醇后减少了皮质醇抑制.
- 在SSD患者和HC患者之间,在下午基线皮质醇,头发皮质醇或皮质醇对压力的反应性方面没有发现显著差异.
结论:
- 这些发现证实了SSD中皮质醇调节的显著变化,包括模糊的甲抑制和白天变化.
- 抗精神病治疗在SSD患者中表现出降低皮质醇的效果.
- 这些结果增强了对SSD中HPA轴失调和皮质醇药理学调节的理解.
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