消灭性门静脉病,正常肝脏和慢性肝脏疾病的共同特征:一个组织学和形态学分析
Peizi Li1, Thomas D Schiano2, Swan N Thung1
1Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
概括
消灭性门静脉病 (OPV) 的诊断是具有挑战性的. 缺失本源门静脉是最常见的OPV特征,与正常肝脏组织学显著不同.
科学领域:
- 肝炎病理学 肝炎病理学
- 肝脏疾病的诊断 肝脏疾病的诊断
- 在病理学中的形态测量.
背景情况:
- 消灭性门静脉病 (OPV) 导致非循环门高血压.
- 由于异质和微妙的特征,OPV诊断很困难.
- OPV可能被误诊为正常的肝脏组织学.
研究的目的:
- 为了将OPV病例与正常肝脏和慢性肝病对照进行比较.
- 为了识别和量化OPV的组织学特征.
- 评估形态测量在OPV检测中的诊断实用性.
主要方法:
- 在三色染色肝脏活检中对门道 (PTs) 和异形门静脉 (PVs) 的形态测量分析.
- 将OPV病例 (n=72) 与正常肝脏 (n=40) 和慢性肝病 (n=40) 的对照进行比较.
- 评估特征,包括风湿性硬化,纤维化,衰变性PV和缺席的本地PV.
主要成果:
- 缺席的本地PV (44.5%) 是最常见的OPV特征.
- 在OPV病例中,与正常对照人群相比,显著增加了缩性PV,神经硬化和PT纤维化.
- 与OPV病例相比,在慢性肝病对照组中,密度纤维化的PT更为频繁.
结论:
- 缺席的本地PV是OPV的关键组织学指标.
- 变质性PVs,神经硬化和PT纤维化是区分OPV与正常肝脏的重要指标.
- 在正常或慢性肝病的肝活检中可能存在OPV特征,需要病理学家的意识.
关键词:
门膜纤维化非循环性门膜纤维化门外高血压非循环性门外高血压.消灭性门静脉病变 (portal venopathy) 是一种门静脉病变.质硬化症 (Phlebosclerosis) 是一种疾病.携带状血管疾病的血管疾病.更多相关视频
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