基底侧杏仁体对积极但不抑制的逃避和寻求奖励的价值依赖的贡献
Gemma L Dalton1, Ian D Daly1, Stan B Floresco1
1Department of Psychology and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada.
Behavioural brain research
|February 22, 2025
概括
底侧杏仁体 (BLA) 对于在复杂的避免和奖励任务中采取行动至关重要,这些任务需要刺激歧视. 它的作用转移到更简单的任务中,对于避免而言至关重要,而不是寻求奖励.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 决策 决策 决策 决策 决策
背景情况:
- 已知底侧杏仁体 (BLA) 影响工具行为,以避免厌恶事件和寻求奖励.
- 复杂的目标导向行为往往需要区分刺激来决定是否采取行动或不采取行动.
研究的目的:
- 在大鼠中研究底侧杏仁体 (BLA) 在不同的避免和寻求奖励策略中的作用.
- 要确定BLA函数是否根据任务复杂性和结果的价值 (厌恶与奖励) 不同.
主要方法:
- 在雄性和雌性大鼠中使用GABA激动剂对基底侧桃体 (BLA) 的非激活.
- 训练老鼠执行涉及主动/抑制性回避和食欲性去/不去歧视的任务.
- 评估单个cue主动避免和奖励任务的表现.
主要成果:
- 当需要刺激歧视时,BLA无活化会影响积极避免和积极寻求奖励.
- 相比之下,BLA无活化稍微增强了抑制性回避,并没有影响抑制性寻求奖励.
- 在更简单,单个cue任务的表现显示,BLA无活化破坏了回避,但没有寻求奖励.
结论:
- 底侧杏仁体 (BLA) 从根本上参与促进基于刺激歧视的行为,以避免和获得奖励.
- 当需要积极的策略时,BLA可能会减弱抑制性回避,但它在更简单的任务中的作用取决于目标的价值.
- BLA对于工具回避至关重要,但对于在初始条件下寻求简单的奖励至关重要.
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