术前口服碳水化合物对接受下肢整形手术的老年患者手术后妄想的作用:一项前性随机试验
Luo-Ting Li1, Xing-Hao Wang1, You-Bo Zuo2,3
1Department of Anesthesiology, North Sichuan Medical College, Nanchong, 637007, Sichuan, China.
在手术前摄入碳水化合物显著降低了经过骨科手术的老年患者手术后 Delirium (POD) 的发生率. 这种干预也帮助缓解了手术后的代谢障碍和炎症反应.
科学领域:
- 老年医学 老年医学
- 麻醉学 麻醉学
- 外科手术的结果
背景情况:
- 手术后痴呆症 (POD) 与代谢障碍和炎症有关.
- 手术前的碳水化合物补充可能会改善胰岛素抵抗力并减少炎症.
- 这项研究调查了下肢手术后老年人POD发病率.
研究的目的:
- 评估手术前口服碳水化合物摄入对POD发病率的影响.
- 评估老年手术患者对代谢和炎症标志物的影响.
主要方法:
- 80名患者被随机分配到碳水化合物溶液组 (CHO组) 或禁食组 (C组).
- 手术前2小时,CHO组消耗了200毫升的碳水化合物溶液;C组禁食了8小时.
- 评估POD发生率,血葡萄糖,IL-6和CRP水平手术前和后.
主要成果:
- 与C组相比,在CHO组观察到较低的POD发病率 (P=0.005).
- 在手术后的第1天和第3天,CHO组的血糖,IL-6和CRP水平显著降低 (P<0.05).
结论:
- 术前口服碳水化合物摄入有效降低老年手术患者的POD发病率.
- 这种益处归因于改善术后代谢障碍和炎症反应.
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