作为泰国老年人群骨质疏松症查工具的FRAX工具的新切割值
Apichat Asavamongkolkul1, Nath Adulkasem1, Ekasame Vanitcharoenkul1
1Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkoknoi, Bangkok, 10700, Thailand.
Scientific reports
|February 22, 2025
概括
这项研究发现了特定的骨折风险评估工具 (FRAX) 截止值,以有效地选泰国老年人的骨质疏松症. 这些值可以帮助预防这个群体的脆弱性骨折.
科学领域:
- 老年医学 老年医学
- 骨质疏松症研究 骨质疏松症研究
- 公共卫生查 公共卫生查
背景情况:
- 在老年人中诊断骨质疏松症对于预防脆弱性骨折至关重要.
- 双能X射线吸收计 (DXA) 是黄金标准,但在广泛查的可用性和成本方面存在局限性.
- 对于老年人群,需要有效的查工具.
研究的目的:
- 确定最佳骨折风险评估工具 (FRAX) 的切断值,用于泰国老年人群的骨质疏松症查.
- 为了评估FRAX在识别骨质疏松症的准确性,与骨矿物质密度 (BMD) 测量相比.
- 为泰国老年人提出一个具有成本效益的骨质疏松症查策略.
主要方法:
- 分析人口统计数据,FRAX骨折 (HF) 和主要骨质疏松性骨折 (MOF) 评分,以及2991名社区居住的泰国成年人≥60岁的BMDT-评分.
- 骨质疏松症定义为BMD T-score ≤ -2.5.5 的骨质疏松症.
- 接收器操作特征 (ROC) 曲线分析以评估FRAX准确性 (曲线下的面积 - AUC).
主要成果:
- 对于骨质疏松症,FRAX 显示了可接受的区分能力:FRAX HF 的 AUC 为 0.75,FRAX MOF 的 AUC 为 0.72.
- 建议的截止值:FRAX HF为1.5和FRAX MOF为4.5.
- 这些切断值在检测骨质疏松症方面实现了高灵敏度 (90.4%) 和负预测值 (89.7%).
结论:
- 在泰国老年人群中查骨质疏松症的有效FRAX截止值.
- 在泰国老年人中,FRAX可以作为初始骨质疏松症查的有价值和易于使用的工具.
- 这种方法支持针对脆弱性骨折预防的有针对性的干预措施.
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