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患者与提尔泽帕提德治疗体重管理的经验:来自SURMOUNT-4的退出访谈

Chloe Carmichael¹, Irina Jouravskaya², Elizabeth Collins¹

¹Clarivate, London, UK.

|February 22, 2025

概括

参与SURMOUNT-4试验的患者报告了铁泽帕提德 (一种体重控制药物) 的显著益处,包括改善食欲和能量. 尽管有副作用,但大多数人发现蒂尔泽帕提德有效,并愿意继续治疗.

科学领域:

药理学和内分泌学药理学和内分泌学
临床试验和患者体验
肥胖和体重管理

背景情况:

蒂尔泽帕提德是一种双重依赖葡萄糖的胰岛素型多和葡萄糖类-1受体激动剂,于2023年获得FDA批准用于体重控制.
在SURMOUNT-4试验中,研究了tirezepatide在肥胖或超重的成年人中的疗效.

研究的目的:

在SURMOUNT-4临床试验期间,以定性的方式探索患者对提尔泽帕提德的体验.
了解参与者对提泽帕提德的益处,管理和整体试验参与的看法.

主要方法:

在线,半结构化的退出面试与美国SURMOUNT-4试验的86名成年参与者进行.
采访的重点是接收蒂尔泽帕提德的经验,使用注射笔设备,以及整体临床试验参与.
用定性内容分析分析了转录的采访.

主要成果:

参与者报告了感知到的好处,如改善食欲控制,增加能量,更好的服装适合.
尽管经历了胃肠道副作用,但参与者普遍赞赏蒂尔泽帕提德的疗效,并发现注射笔易于使用.
大多数参与者表示愿意继续治疗tirezepatide.

结论:

蒂尔泽帕提德治疗导致了超出其药理效应的感知生活改善,尽管注意到了副作用.
定性退场访谈为患者体验和临床试验参与的更广泛影响提供了宝贵的见解.
参与者愿意继续服用蒂尔泽帕蒂德表明整体体验是积极的,尽管承认了面试参与中的潜在选择偏差.

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