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Updated: May 26, 2025

Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
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Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells

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在DNMT3A突变的造血干细胞/原始细胞中,STING介导了增加的自我更新和谱系歪曲

Jingru Huang1, Jiaying Xie2, Yin Wang1

  • 1Center of Precision Medicine for Blood Diseases, Huashan Hospital, Zhongshan-Xuhui Hospital, Chinese Academy of Medical Sciences (RU069), Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai, 200032, China.

Leukemia
|February 22, 2025
PubMed
概括

在DNA甲基转移酶3A (DNMT3A) 的体质突变通过激活STING通路来驱动白血病. 抑制STING可以纠正异常细胞生长,并在临床前模型中减少白血病的进展,从而提供了一个新的治疗点.

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