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吸烟,饮酒和心房动:孟德尔随机化研究

Xuejiao Ye¹, Qian Wu¹, Qianyu Lv¹

¹Department of Cardiovascular Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange, Xicheng District, Beijing, China.

Cardiovascular toxicology

|February 22, 2025

概括

积极吸烟显著增加了心房动 (AF) 的风险. 这项研究发现,二手烟或酒精消费与AF之间没有因果关系,这突显了戒烟对心血管健康的重要性.

科学领域:

心血管流行病学心血管流行病学
遗传流行病学遗传流行病学
公共卫生公共卫生

背景情况:

心血管疾病,包括心房动 (AF),对全球健康造成重大负担.
吸烟,接触二手烟和饮酒已成为心血管疾病的风险因素.
这些生活方式因素和AF之间的因果关系仍然不确定,需要进行严格的调查.

研究的目的:

调查活跃吸烟,二手烟暴露,酒精消费和心房动 (AF) 之间的潜在因果关系.
区分各种吸烟表型 (目前,永远,轻度吸烟者) 和酒精消费对AF风险的病因作用.
采用孟德尔的随机化来克服传统观察研究在确定因果关系方面的局限性.

主要方法:

进行了两样本的门德尔随机化 (MR) 分析,使用遗传变异作为仪器变量.
吸烟 (当前,永远,轻) 和酒精消费表型的数据来源于IEU开放GWAS项目.
逆变量加权 (IVW) 是主要的MR方法,加上加权中位数,MR-Egger,MR-PRESSO,并为稳定性留出一个分析. 还进行了反向MRI.

主要成果:

门德尔的随机化分析提供了基因证据,支持活跃吸烟 (目前,曾经和轻度吸烟者) 与增加AF风险之间的因果关系.
没有发现二手烟暴露或酒精消费表型和心房动之间存在显著的因果关系.
反向门德尔随机化分析没有表明任何反向因果关系的证据,其中AF影响活跃吸烟.

结论:

这项研究提供了强有力的MR证据,证实了活跃吸烟和心房的发展之间存在因果关系.
强烈建议戒烟作为预防和减轻AF风险的关键策略.
需要进一步的研究来澄清二手烟暴露和酒精消费对AF病因学的具体影响.

关键词:

积极吸烟积极吸烟积极吸烟酒精消费酒精消费酒精消费心房动是一种心房动.门德尔的随机化暴露于二手烟雾中的时间.吸烟吸烟吸烟吸烟

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