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揭示肺部瘤中新目标,以提高放射治疗效率:综合性审查

Faris Anad Muhammad¹, Ayat Hussein Adhab², Morug Salih Mahdi³

¹College of Pharmacy, Alnoor University, Nineveh, Iraq.

Journal of biochemical and molecular toxicology

|February 23, 2025

概括

肺癌的放射治疗耐药性是复杂的,涉及瘤细胞及其微观环境. 针对DNA损伤反应和瘤微环境提供了新的策略,以提高放射治疗的有效性.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
癌症生物学癌症生物学

背景情况:

放射治疗是肺癌的主要治疗方法,但放射电阻限制了它的有效性.
肺瘤具有复杂的机制,包括DNA损伤反应 (DDR) 和瘤微环境 (TME) 相互作用,促进对电离辐射 (IR) 的抵抗.

研究的目的:

在放射电阻的背景下,审查肺瘤及其微环境的复杂性.
在肺瘤和TME中确定新的点,用于放射敏感化策略.

主要方法:

关于肺癌放射电阻研究的综合文献综述.
分析肺癌细胞,TME和对电离辐射的反应之间的相互作用.
识别和分类潜在的辐射敏感化目标.

主要成果:

肺癌细胞使用增强的DNA损伤反应 (DDR) 和细胞死亡抑制来抵抗红外线.
构成免疫细胞,树皮细胞和分子介质的TME显著促进了放射电阻.
辐射敏感化的主要目标包括DDR通道,免疫抑制元素,缺氧和益血管性因素.

结论:

了解复杂的肺瘤和TME相互作用对于克服放射电阻至关重要.
准DDR通路,免疫抑制细胞,缺氧和益血管性介质提供了增强放射治疗疗效的有希望的策略.
将放射治疗与免疫调节剂和抑制剂等新型药物结合起来,为改善肺癌治疗结果提供了一条道路.

关键词:

对DNA损伤的反应反应免疫检查点抑制剂免疫检查点抑制剂肺癌是一种肺癌.辐射疗法辐射疗法瘤微环境是一个微环境.

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