用于分量剂量IPV的Tropis无针针注射器:试点研究,将其纳入古巴的常规免疫服务
Sonia Resik1, Rocio Lopez Cavestany2, Alina Tejeda3
1Instituto de Medicina Tropical "Pedro Kourí", La Habana, Cuba.
Vaccine
|February 23, 2025
概括
没有针的Tropis喷气注射器是家长和护士在古巴为分量注射非活化脊髓灰质炎疫苗 (fIPV) 的首选. 尽管Tropis的接受度很高,安全性和免疫性与针和注射器方法相似,但由于成本,Tropis并未被采用.
科学领域:
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
- 医疗器械 医疗器械
背景情况:
- 古巴在其常规免疫计划中使用分量无活化脊髓灰质炎疫苗 (fIPV).
- 无针喷气注射器为疫苗注射提供了一个潜在的替代方案.
- 在Tropis无针喷气注射器试点用于皮内fIPV输送.
研究的目的:
- 为了评估Tropis无针喷射器的可接受性,安全性和免疫性,与fIPV.fIPV的传统针和注射器 (N / S) 管理相比.
- 为了评估家长和护理人员对Tropis设备的满意度.
主要方法:
- 一项比较研究在古巴卡马古伊和西戈德阿维拉进行 (2019-2020年).
- 调查评估了5260名家长/监护人和66名护士的满意度.
- 对231名用Tropis接种疫苗的儿童和138名用N/S接种疫苗的儿童的中和性脊髓灰质炎抗体水平进行了分析.
主要成果:
- 特洛皮斯的接受度很高,有98%的家长和98.5%的护士更喜欢它,而不是NS.
- 与N / S (13%) 相比,Tropis (6%) 的不良事件明显较低.
- 在任何脊髓灰质炎病毒血清型的两个剂量后,在Tropis和N/S组之间没有观察到血清流行率的显著差异.
结论:
- 在Tropis无针喷气注射器显示高的可接受性和安全性fIPV管理.
- 通过Tropis输送的fIPV的免疫性与N / S管理相当.
- 尽管有良好的临床结果,但与Tropis设备相关的成本增加阻止了其在古巴的常规免疫计划中实施.
相关概念视频
01:21Drug Accumulation During Multiple Dosing: Repetitive IV Injections
527
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
527
01:28Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices
208
Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
208
01:21Intrauterine Drug Delivery Systems
168
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
168