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脑卒中的严重程度会影响纤维素原与血栓消毒疗法后神经系统早期恶化的相关性

Shuhong Yu¹, Jijun Shi², Shiping Guo³

¹Department of Encephalopathy, Suzhou Integrated Traditional Chinese and Western Medicine Hospital, Suzhou 215101, China.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

|February 23, 2025

概括

静脉血栓溶解 (IVT) 后的纤维素水平与中风患者的早期神经系统恶化 (END) 相相关. 这种关联在患有更严重中风的患者中更为强烈,NIHSS得分更高表明了这一点.

科学领域:

神经学神经学
生物化学生化学

背景情况:

早期神经系统恶化 (END) 是急性缺血性中风 (AIS) 后的一个关键并发症.
纤维素素是凝血中的关键蛋白质,已与中风病理生理学和结果有关.

研究的目的:

检查基线和血栓溶解后纤维素水平和AIS患者的END之间的关系.
为了确定中风的严重程度是否会改变纤维素和END之间的关联.

主要方法:

在364名AIS患者的入院和24小时静脉血栓溶解 (IVT) 后测量纤维素素水平.
使用回归和分层分析,包括相互作用测试,以评估纤维素原-END关系和中风严重程度的影响 (NIHSS分数).

主要成果:

基线纤维素素与END没有显著的关联.
在IVT24小时后纤维素水平升高与END风险增加有关 (OR,1.49;P=0.0479).
这种关联仅在中风严重程度较高 (NIHSS≥6;OR,1.90;P=0.0120) 的患者中显著,具有显著的相互作用效应 (P=0.0366).

结论:

在IVT24小时后测量的纤维素水平,而不是在基线时,与END独立相关.
脑中风的严重程度显著影响了IVT后纤维素水平和END风险之间的相关性.

关键词:

早期的神经系统恶化.纤维素原蛋白是一种纤维素.脑卒中的严重程度脑卒中严重程度血栓溶解是一种血栓溶解.

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