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双甲暴露改变了老年雌性猛的前列腺中的荷尔蒙调节和反应能力

Luara Jesus Ferrato¹, Thalles Fernando Rocha Ruiz², Lorena Gabriela de Souza¹

¹Microscopy and Microanalysis Center, Department of Biological Sciences, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University - UNESP, SP, Brazil.

Molecular and cellular endocrinology

|February 23, 2025

概括

对双A (BPA) 的暴露会改变女性前列腺中的激素受体和酶. 这种内分泌干扰可能会导致恶性病变的进展.

科学领域:

内分泌学在内分泌学.
生殖生物学生殖生物学
毒理学毒理学毒理学

背景情况:

雌性前列腺是一个由类固醇激素调节的腺体,容易受到内分泌干扰物,如双A (BPA) 的影响.
暴露于BPA与前列腺恶性病变的进展有关.

研究的目的:

为了研究在发育期间暴露于BPA后,雌性 gerbil 前列腺的荷尔蒙调节和响应能力.
为了分析激素受体,类固醇酶和繁殖标志物的变化,在暴露于BPA的老年雌性大鼠中进行分析.

主要方法:

幼犬在怀孕和哺乳期间暴露于BPA (50μg/kg/天).
来自18个月大的大猩猩的前列腺组织使用组织学和免疫组织化学技术进行分析.
测量了雄激素受体 (AR),雌激素受体 (ERα,ERβ),益生素受体 (PRL),孕激素受体 (PR),5α-减少酶,芳酶,PHH3和EZH2的表达.
蛋白质水平通过Western blot评估,并进行形态和形态测量分析.

主要成果:

暴露于BPA会增加AR和ERα的上皮表达,同时降低ERβ表达.
观察到上皮5α-减少酶和芳香酶表达的减少.
增加了扩散标记PHH3和表观遗传标记EZH2的表达.
西方斑点证实了关键受体和酶的蛋白质定量显著差异.

结论:

BPA通过改变女性前列腺中的激素受体表达和酶活性,显著调节前列腺内激素.
这些由BPA引起的变化可能会促进女性前列腺组织恶性病变的进展.
该研究强调BPA是女性前列腺健康的潜在风险因素.

关键词:

双 A 是一种双.酶是一种酶.女性前列腺的前列腺.激素受体是激素受体的组成部分.病变的病变病变的病变

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