相关实验视频

Updated: May 26, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

二甲胺素通过调节氧化应激和免疫失衡来抑制自身免疫性甲状腺炎的发展

Shuangjie Zhu¹, Yongqi Cui¹, Huizheng Hu²

¹Graduate School, Liaoning University of Traditional Chinese Medicine, Shenyang, PR China.

Free radical biology & medicine

|February 23, 2025

概括

甲状腺甲状腺素 (DHA) 是通过减少甲状腺自身抗体和炎症来治疗自身免疫甲状腺炎的前景. 它通过重新平衡T细胞免疫力和通过Nrf2通路促进抗氧化防御来起作用.

科学领域:

内分泌学在内分泌学.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

自身免疫性甲状腺炎是一种常见的内分泌疾病,其原因不明,治疗方法有限.
氧化应激和T细胞免疫失衡与其病变产生有关.

研究的目的:

研究二甲胺素 (DHA) 对自身免疫性甲状腺炎的治疗潜力.
探索涉及氧化应激和T细胞调节的潜在机制.

主要方法:

网络药理学分析以预测DHA的影响.
实验性自身免疫甲状腺炎 (EAT) 鼠标模型用于验证.
对血清自身抗体,甲状腺内炎症,T细胞细胞因子和氧化应激标志物 (GSH,SOD,Nrf2) 的检测.

主要成果:

高剂量的DHA显著降低了EAT小鼠的血清TgAb水平和甲状腺炎症.
DHA调节T细胞反应,降低IFN-γ,IL-17A和IL-6的调节,同时提高IL-4和IL-10的调节.
通过增强GSH,SOD和Nrf2表达,DHA增加了甲状腺组织的抗氧化能力.

结论:

DHA可能会抑制自身抗体的产生,并减少甲状腺炎症.
治疗效果很可能通过恢复T细胞免疫平衡和通过Nrf2通路增强抗氧化防御来调解.
DHA为自身免疫性甲状腺炎提供了潜在的治疗剂.

关键词:

抗氧化剂是一种抗氧化剂.自免疫性甲状腺炎的发生.这是一种二甲胺氨酸.免疫调节是一种免疫调节.

更多相关视频

Author Spotlight: Treating Knee Osteoarthritis with Tuina - A New Perspective

Author Spotlight: Treating Knee Osteoarthritis with Tuina - A New Perspective

Published on: January 12, 2024

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

相关概念视频

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...