埃塞俄比亚多药耐药结核病患者的二线耐药性:基于实验室的监测
Getu Diriba1, Ayinalem Alemu2, Bazezew Yenew1
1Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Journal of global antimicrobial resistance
|February 23, 2025
概括
这项研究在埃塞俄比亚的多药耐药结核病 (MDR-TB) 患者中发现2.35%的前广泛耐药结核病 (XDR-TB) 和1.07%的广泛耐药结核病 (XDR-TB). 持续监测对于控制耐药结核病传播至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 多药耐药结核病 (MDR-TB) 构成了全球重大卫生挑战.
- 埃塞俄比亚面临着相当大的结核病负担,需要了解耐药性模式.
- 对二线抗结核药物新出现的耐药性,包括前广泛耐药性结核病 (XDR-TB) 和广泛耐药性结核病 (XDR-TB),需要紧急调查.
研究的目的:
- 确定埃塞俄比亚MDR-TB患者中二线抗结核药物耐药性的流行率.
- 确定在MDR-TB患者群体中XDR-TB前和XDR-TB的比例.
- 为该地区耐药结核病 (DR-TB) 的监测和治疗策略提供信息.
主要方法:
- 在埃塞俄比亚国家结核病参考实验室 (NTRL) 进行了一项前性,基于实验室的横截面研究.
- 进行了表型药物敏感性测试 (pDST),以评估对二线抗结核药物的耐药性.
- 用SPSS版本23的描述性统计数据分析了数据.
主要成果:
- 在468名MDR-TB患者中,11名 (2.35%) 患有XDR-TB前,五名 (1.07%) 患有XDR-TB.
- 在0.85%的病例中发现对诺基诺 (FQs) 和贝达基林的耐药性.
- 在四个案例中发现了对二线药物的获得性耐药性.
结论:
- 该研究在埃塞俄比亚的MDR-TB病例中发现了XDR-TB前和XDR-TB的显著流行率.
- 持续监测和量身定制的治疗方法对于控制DR-TB至关重要.
- 将基因组监测纳入常规监测可以增强早期检测并改善患者管理.
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