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O-GlcNAcAtlas 4.0:一个更新的蛋白质O-GlcNAcylation数据库与特定站点的量化

Chunyan Hou¹, Weiyu Li², Yaoxiang Li¹

¹Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20007, USA.

Journal of molecular biology

|February 23, 2025

概括

现在O-GlcNAcAtlas 4.0数据库包括定量O-GlcNAcylation数据. 该资源整合了5,400多个量化事件,用于3,130个独特的O-GlcNAc站点,帮助蛋白质修饰研究.

科学领域:

生物化学生物化学
蛋白质组学是指蛋白质组学.
系统生物学系统生物学

背景情况:

与O相关的β-N-乙糖胺 (O-GlcNAc) 修饰 (O-GlcNAcylation) 是一种动态的细胞内转化后修饰,调节许多生物过程.
特定于位点的O-GlcNAc蛋白质组学显著提高了对O-GlcNAc蛋白质组的理解.
像O-GlcNAcAtlas这样的现有数据库主要提供O-GlcNAc蛋白质,和位点的定性数据.

研究的目的:

为O-GlcNAcylation量化数据建立一个全面的数据库.
更新 O-GlcNAcAtlas 资源以定量信息,创建 O-GlcNAcAtlas 4.0.0,以创建一个 O-GlcNAcAtlas 4.0.0.
通过提供蛋白质O-GlcNAcylation动态来促进功能性研究.

主要方法:

系统地策划已发表的文献报告O-GlcNAcylation量化实验.
量化值与特定O-GlcNAc地点和实验细节的整合.
开发O-GlcNAcAtlas 4.0作为O-GlcNAc数据的定性和定量集中存储库.

主要成果:

从已发表的研究中整合了大约5,400个量化事件.
包括3130个独特O-GlcNAc站点的数据.
量化值的详细目录以及实验背景 (样本来源,条件,方法).

结论:

O-GlcNAcAtlas 4.0是一个独特的,免费访问的数据库,提供定性和定量O-GlcNAcylation数据.
更新的数据库作为蛋白质O-GlcNAcylation动态的全面资源.
这种资源将极大地帮助生物医学界对O-GlcNAcylation的功能性研究.

关键词:

这就是O-GLcNAcc.在O-GlcNAc蛋白质组学中.这是一种O-GlcNAcylation.量化量化的量化量化量化的量化量化量.

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