抑郁成年人饮食模式与自杀念头之间的关联:来自NHANES 2007-2020年的见解
Kun Li1, Honggang Lyu2, Lihong Zhang3
1Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, China; Clinical Laboratory, Affiliated Hospital of West Anhui Health Vocational College, Lu'an, Anhui, China.
Journal of affective disorders
|February 23, 2025
概括
肠道微生物群的饮食指数 (DI-GM) 显示,与具有自杀念头的大型抑郁症 (MDD + SI) 有显著的负面关联. 促进肠道微生物群的多样性可能会降低MDD + SI风险.
科学领域:
- 营养精神病学 营养精神病学
- 心理健康研究 心理健康研究
- 肠道微生物组研究 研究肠道微生物组
背景情况:
- 饮食模式显著影响主要抑郁症 (MDD) 风险.
- 有限的研究存在于饮食模式和MDD与自杀念头 (MDD + SI).
- 五个指数 (HEI-2015,DII,CDAI,OBS,DI-GM) 通过炎症,抗氧化能力和肠道微生物群来评估饮食.
研究的目的:
- 调查五种饮食指数和MDD + SI之间的关联.
- 检查饮食模式与心理健康结果之间的关系.
主要方法:
- 利用了23621名参与者的数据 (2007-2020年NHANES).
- 使用PHQ-9.9进行评估MDD和SI.
- 采用加权多变量逻辑回归,子组分析和受限立方线 (RCS) 模型.
主要成果:
- 所有五个指数都与MDD相关;只有DI-GM显示出与MDD + SI有显著的负相关性.
- 在前吸烟者,肥胖者,高血压或糖尿病患者中,相关性更强.
- DI-GM证明了与MDD的非线性关系,以及与MDD+SI的线性剂量反应.
结论:
- 在DI-GM和MDD + SI之间存在显著的关联.
- 针对肠道微生物群多样性的饮食干预措施可能会降低MDD + SI风险.
- 由于横截面设计,无法确定因果关系.
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